) As to antacids -- unless you want to space them 3 hours away from the riba -- best to ask your doc for an H-2 Pump like Pepcid AC or a PPI like Nexium. Compare Pepcid AC vs Prilosec head-to-head for uses, ratings, cost, side effects, interactions and more. Pepcid AC rated 5.0/10 vs Prilosec rated 7.9/10 in overall patient satisfaction. Pepcid AC rated 5.0/10 vs Prilosec rated 7.9/10 in overall patient satisfaction. Nexium (esomeprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day. You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need quicker relief. Compare Nexium vs. Pepcid AC, which is better for uses like: GERD, Heartburn and Reflux. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Pepcid AC 4.5/5 over Nexium 3.4/5 in overall satisfaction. Maximum Strength PEPCID AC® works before, during, or after the start of heartburn. Even at night, Maximum Strength PEPCID AC® works fast to relieve heartburn and is strong enough to prevent tough heartburn.* Compare Nexium vs Pepcid head-to-head for uses, ratings, cost, side effects, interactions and more. Nexium rated 7.9/10 vs Pepcid rated 7.0/10 in overall patient satisfaction. Nexium rated 7.9/10 vs Pepcid rated 7.0/10 in overall patient satisfaction. I have been taking Nexium 40 mg twice a day for GERD for several years with great result. Notheless once in a blue moon I will get all day long heartburn (pretty bad like today). Now (I am normal weight now), when I remember, I take Pepcid AC and it seems to solve the problem for the next night. I am thinking of taking Prilosec or Nexium to permanently stop this from happening. What do you think? I really have found that Depokote helps me with dealing with my anger and with life in ways that I don't understand at all. Compare Nexium vs. Pepcid, which is better for uses like: GERD, Heartburn and Reflux. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Pepcid 4/5 over Nexium 3.4/5 in overall satisfaction. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fried on nexium vs pepcid.To what will help with a distended abdomen depends entirely on the cause of the distention. Probiotics are helpful with a lot of digestive issues, if you take them regularly. The two meds you mention reduce stomach acid and are unlikely to help with distention. If this is happening.